Is it possible to refresh a DIV without another page inside the DIV?

Is it possible to refresh a DIV without another page inside the DIV?

as the title says, is it possible to refresh a div without another html or
php page inside of the div?
for example this is what can be done using jquery and ajax:
$(document).ready(function () {
$('#mydiv').delay(10000).load('page.php');
});
My Div shows/holds a data which is pulled from the mysql database and it
doesn't have page.php inside it.
I've searched for this and all the results were similar to the one i
posted above!
is this even possible and if so how?